Sensyne joins GOSH for clinical AI research in childhood diseases

Sensyne and GOSH partner to apply clinical AI in childhood disease research

OXFORD, U.K: Sensyne Health plc has signed a five year non-exclusive Strategic Research Agreement (SRA) with Great Ormond Street Hospital for Children NHS Foundation Trust (GOSH) to analyse anonymised patient data using clinical artificial intelligence (Clinical AI) technology.

The purpose of the SRA is to enable the ethical application of Clinical AI research to improve paediatric clinical outcomes, and accelerate research into new medicines to find new and better ways to treat rare and complex childhood diseases.

The SRA is Sensyne’s first to focus on improving care and accelerating the development of medicines specifically for children.

The first project will focus on developing a clinical decision support algorithm to help clinicians caring for children with chronic kidney disease. This will then be used to develop further clinical support algorithms for other diseases in children.

Development of paediatric medicines, from discovery through clinical development, has long been especially challenging. Recent developments in Clinical AI and the use of real world data provide an opportunity to develop new medicines and to accelerate the clinical development of treatments for childhood illnesses. This will be a key focus of the research that Sensyne and GOSH will seek to develop.

Matthew Shaw, Chief Executive of Great Ormond Street Hospital, said: “At GOSH we treat patients with the most rare and complex conditions. Research into developing new diagnosis and treatments is vital and we are always looking to find ways to improve patient outcomes, while making sure their information is safe and secure.

Children are at the heart of everything we do and this collaboration is no different. It will offer the potential to use digital innovation to find and develop diagnosis and treatments much faster, not just for GOSH patients but children across the country and internationally.”

Lord (Paul) Drayson PhD, CEO of Sensyne Health, said: “We are delighted to be undertaking research in partnership with Great Ormond Street Hospital, widely recognised as one of the leading centres for children’s healthcare and research in the world.

GOSH has invested heavily in its digital infrastructure and curation of its data which means we can start work immediately: together we aim to use the power of ethical AI to make a real difference in finding new and better ways to treat rare and complex childhood diseases and in future to develop a world-wide research community using ethical AI to improve the lives of children world-wide.”

This new SRA provides non-exclusive access to longitudinal de-identified and anonymised patient data for analysis by Sensyne using its expertise in clinical AI. The dataset covers a patient population of approximately 320,000 people.

Research will be undertaken to the highest standards of information governance and data security in accordance with NHS principles, the UK Government Code of Practice and data protection legislation. All data accessed by Sensyne will be anonymised by GOSH beforehand and the provision of the data will operate under an agreed Data Processing Protocol (“DPP”) under GOSH governance oversight.

GOSH patient data is stored securely within GOSH’s Digital Research Environment, a research platform hosted on Microsoft Azure Cloud which will facilitate safe, efficient data processing by Sensyne and enable immediate commencement of research.

GOSH will receive 1,428,571 new ordinary shares of ten pence nominal value (“New Ordinary Shares”) representing 0.9% of the current issued share capital and bringing the total share ownership held by NHS Trusts in Sensyne to approximately 13.8%.

GOSH is also eligible to receive up to a further 1,428,570 ordinary shares, payable in three tranches that are each dependent on the achievement of specific discovery research project milestones.

GOSH will also receive from Sensyne an investment of £250,000 per year over the 5-year term of the contract for specific investments in information technology to enable the curation and analysis of data under the SRA. GOSH will also receive a royalty on revenues that are generated by Sensyne from the research undertaken under the SRA.

Any financial return GOSH receives from Sensyne will be reinvested to facilitate research that will ultimately improve patient care. GOSH has entered into a lock-up agreement whereby it has agreed not to dispose of any shares for a period of two years from the date the shares are issued.

The issue of New Ordinary Shares in Sensyne Health to the Great Ormond Street Hospital NHS Foundation Trust remains subject to receipt of a s593 report by the Company and a further announcement will be made in due course once the shares have been allotted and expected to be admitted to trading on AIM.

Sensyne Health PLC

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1 Sep, 4:35 pm GMT+1 ·Disclaimer

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